Cedars-Sinai Cancer: Cancer Immunology Club Meeting

Modulating Cellular Senescence and its Secretory Phenotype for Cancer Immunotherapy

Marcus Ruscetti, PhD
Associate Professor
Molecular, Cell and Cancer Biology Department
Deputy Director, Cancer Biology Graduate Program
University of Massachusetts Chan Medical School

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Apr 13 2026

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Date: Apr 13 2026
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Cedars-Sinai Cancer: Cancer Immunology Club Meeting

Modulating Cellular Senescence and its Secretory Phenotype for Cancer Immunotherapy

Marcus Ruscetti, PhD Associate Professor Molecular, Cell and Cancer Biology Department Deputy Director, Cancer Biology Graduate Program University of Massachusetts Chan Medical School

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Donna Hansel, MD, PhD

Division Head, Pathology and Laboratory Medicine, MD Anderson Cancer Center

David M. Engman, MD, PhD

Chair Emeritus of Pathology and Laboratory Medicine, Cedars-Sinai Retired Professor of Microbiology-Immunology and Pathology, Northwestern University Feinberg School of Medicine

Peiwen Chen, PhD

Associate Staff/Professor, Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic

Dalnim Cho, PhD

Assistant Professor, Department of Health Disparities Research, Division of Cancer Prevention and Population Sciences, The University of Texas MD Anderson Cancer Center

Abby Green, MD

Associate Professor of Pediatrics, Infectious Diseases, Washington University School of Medicine in St. Louis

Berkley Gryder, PhD

Assistant Professor, Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine Assistant Professor, Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine

Hae Lin Jang, PhD

Associate Professor of Medicine, Brigham and Women’s Hospital

Michael Jackson, PhD

Senior Vice President, Drug Discovery and Development, Conrad Prebys Center for Chemical Genomics, Sanford Burnham Prebys Adjunct Professor, Cell and Molecular Biology of Cancer Program, Sanford Burnham Prebys

Cato T. Laurencin, MD, PhD

Robert G. Rowe, MD, PhD

Assistant Professor of Pediatrics, Boston Children’s Hospital

Nilay Sethi, MD, PhD

Assistant Professor of Medicine, Harvard Medical School Physician, Medical Oncology, Dana-Farber Cancer Institute Associate Physician, Medical Oncology, Brigham And Women’s Hospital

Min Xue, PhD

Associate Professor of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai

Peter Kuhn, PhD

Deputy Director, Convergent Science Virtual Cancer Center Director, USC Michelson Convergent Science Institute in Cancer University Professor of Biological Sciences, Medicine, Biomedical Engineering, Aerospace & Mechanical Engineering, and Urology University of Southern California

Kenneth A. Bertram, MD, PhD

Special Advisor on Military Health, Convergent Science Virtual Cancer Center Clinical Product Development Officer, Wake Forest Institute for Regenerative Medicine Medical Director, Center for Defense Medicine, BioGenerator Colonel, United States Army, Ret.

Thomas R. Cech, PhD

Chair, Convergence Council Distinguished Professor of Biochemistry, University of Colorado Boulder Director, University of Colorado BioFrontiers Institute Investigator, Howard Hughes Medical Institute

Stephen J. Freedland, MD

James Hu, MD, FACP

Clinical Associate Professor of Medicine, Co-Director of the Adolescent Young Adult (AYA) Oncology Program and Medical Director of the Sarcoma Program, USC Norris Comprehensive Cancer Center Colonel, United States Army Reserve (USAR), Ret.

Amanda Randles, PhD

Alfred Winborne and Victoria Stover Mordecai Assistant Professor of Biomedical Sciences, Duke University Assistant Professor of Biomedical Engineering and Computer Science, Duke University

Jan Liphardt, PhD

Associate Professor of Bioengineering, Stanford University

Nancy Krunic, PhD

Vice President and Global Head of Diagnostic Sciences and Partnerships, Novartis

Yu-Chong Tai, PhD

Anna L. Rosen Professor of Electrical Engineering and Medical Engineering, California Institute of Technology Andrew and Peggy Cherng Medical Engineering Leadership Chair and Executive Officer for Medical Engineering

Ian M. Thompson Jr., MD

Emeritus Professor, University of Texas The Children’s Hospital of San Antonio Foundation

Rodney Page, DVM, MS

Stephen J Withrow Presidential Chair in Oncology, Colorado State University Professor of Oncology, Colorado State University Director, Flint Animal Cancer Center

Deborah Lafer Scher, MBA

Independent Board Director

Ekso Bionics

Angela Lai, MSE

Chief Executive Officer, BetterOmics

Marcus Ruscetti, PhD
Associate Professor
Molecular, Cell and Cancer Biology Department
Deputy Director, Cancer Biology Graduate Program
University of Massachusetts Chan Medical School

Chair Emeritus of Pathology and Laboratory Medicine, Cedars-Sinai
Retired Professor of Microbiology-Immunology and Pathology, Northwestern University Feinberg School of Medicine

Assistant Professor, Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine
Assistant Professor, Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine

Senior Vice President, Drug Discovery and Development, Conrad Prebys Center for Chemical Genomics, Sanford Burnham Prebys
Adjunct Professor, Cell and Molecular Biology of Cancer Program, Sanford Burnham Prebys

Assistant Professor of Medicine, Harvard Medical School
Physician, Medical Oncology, Dana-Farber Cancer Institute
Associate Physician, Medical Oncology, Brigham And Women’s Hospital

Deputy Director, Convergent Science Virtual Cancer Center
Director, USC Michelson Convergent Science Institute in Cancer
University Professor of Biological Sciences, Medicine, Biomedical Engineering, Aerospace & Mechanical Engineering, and Urology University of Southern California

Special Advisor on Military Health, Convergent Science Virtual Cancer Center
Clinical Product Development Officer, Wake Forest Institute for Regenerative Medicine
Medical Director, Center for Defense Medicine, BioGenerator
Colonel, United States Army, Ret.

Chair, Convergence Council
Distinguished Professor of Biochemistry, University of Colorado Boulder
Director, University of Colorado BioFrontiers Institute
Investigator, Howard Hughes Medical Institute

Clinical Associate Professor of Medicine, Co-Director of the Adolescent Young Adult (AYA) Oncology Program and Medical Director of the Sarcoma Program, USC Norris Comprehensive Cancer Center
Colonel, United States Army Reserve (USAR), Ret.

Alfred Winborne and Victoria Stover Mordecai Assistant Professor of Biomedical Sciences, Duke University
Assistant Professor of Biomedical Engineering and Computer Science, Duke University

Anna L. Rosen Professor of Electrical Engineering and Medical Engineering, California Institute of Technology
Andrew and Peggy Cherng Medical Engineering Leadership Chair and Executive Officer for Medical Engineering

Emeritus Professor, University of Texas
The Children’s Hospital of San Antonio Foundation

Stephen J Withrow Presidential Chair in Oncology, Colorado State University
Professor of Oncology, Colorado State University
Director, Flint Animal Cancer Center

President and Chief Scientific Officer, Caris Life Sciences
Adjunct Faculty, Arizona State University
Board Member, Biden Cancer Initiative Standards Group

Patient Advocate, Convergent Science Virtual Cancer Center
National Advocate, National Cancer Institute’s Physical Sciences-Oncology Program
Member, Institutional Review Board, Baylor Research Institute

Chair, Department of Neurological Surgery, Northwestern University Feinberg School of Medicine
Michael J. Marchese Professor of Neurosurgery and Professor of Neurological Surgery, Northwestern University Feinberg School of Medicine

Patient Advocate, Convergent Science Virtual Cancer Center
Member, Institutional Review Board, Cedars-Sinai

Gertrude Donnelly Hess Professor of Oncology
Professor, Department of Genetics & Genome Sciences, Case Western Reserve University School of Medicine

Associate Professor of Medicine at Harvard Medical School and Harvard-MIT Health Sciences and Technology
Associate Bioengineer, Department of Medicine, Brigham And Women’s Hospital
Principal Investigator, Dana Farber Cancer Institute

Professor of Medicine, Harvard Medical School
Distinguished Physician, Dana-Farber Cancer Institute
Deputy Director, Dana-Farber/Harvard Cancer Center

Director, Stem Cell Research Program, Boston Children’s Hospital
Grousbeck Professor of Pediatrics, Harvard Medical School

Oliver H. Beahrs Professor of Surgery Uniformed Services
University Murtha Cancer Center (MCC) Director, Walter Reed National Military Medical Center
Colonel, United States Army, Ret.

Professor of Cardiology, Biomedical Sciences, Pathology and Laboratory Medicine, Director of Basic Science Research in the Barbara Streisand Women’s Heart Center
Cedars-Sinai Medical Center

Professor and Director, Cancer & Cell Biology Division
Translational Genomics Research Institute (TGen)