{"id":8060,"date":"2022-07-12T12:22:39","date_gmt":"2022-07-12T19:22:39","guid":{"rendered":"https:\/\/csvcc.org\/?page_id=8060"},"modified":"2025-10-16T14:41:04","modified_gmt":"2025-10-16T21:41:04","slug":"csvcc-leadership-research","status":"publish","type":"page","link":"https:\/\/csvcc.org\/?page_id=8060","title":{"rendered":"CSVCC Leadership Research"},"content":{"rendered":"
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CSVCC LEADERSHIP RESEARCH<\/h1>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n
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Dan Theodorescu, MD, PhD<\/h1>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n
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Recent Publications<\/h4>\n <\/div>\n <\/div>\n
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Chen X, Shen Y, Choi S, Abdel-Hafiz HA, Basu M, Hoelzen L, Tufano M, Kailasam Mani SK, Ranjpour M, Zhu J, Ramanujan VK, Koltsova EK, Calsavara VF, Knott SRV, <\/span>Theodorescu D.<\/strong>\n \n Concurrent loss of the Y chromosome in cancer and T cells impacts outcome<\/u>\n <\/a>\n .<\/u> Nature. 2025 Jun 4. doi: 10.1038\/s41586-025-09071-2. Epub ahead of print. PMID: 40468066.<\/span><\/p>\n

Feldman LER, Mohapatra S, Jones RT, Scholtes M, Tilton CB, Orman MV, Joshi M, Deiter CS, Broneske TP, Qu F, Gutierrez C, Ye H, Clambey ET, Parker S, Mahmoudi T, Zuiverloon T, Costello JC, Theodorescu D<\/strong>.\n \n Regulation of volume-regulated anion channels alters sensitivity to platinum chemotherapy<\/u>\n <\/a>. Science Adv. 2024 Dec 13;10(50):eadr9364.<\/p>\n

Osipov A, Nikolic O, Gertych A, Parker S, Hendifar A, Singh P, Filippova D, Dagliyan G, Ferrone C, Zheng L, Moore J, Tourtellotte W, Van Eyk J, <\/span>\n Theodorescu D<\/strong>. <\/span>\n \n The Molecular Twin artificial-intelligence platform integrates multi-omic data to predict outcomes for pancreatic adenocarcinoma patients<\/u>\n <\/a>. Nature Cancer (2024).
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Abdel-Hafiz HA, Schafer JM, Chen X, Xiao T, Gauntner TD, Li Z, <\/span>Theodorescu D<\/strong>\n . <\/span>\n \n Y Chromosome Loss in Cancer Drives Growth by Evasion of Adaptive Immunity<\/u>\n <\/a>. Nature. 619, 624-631 (2023).
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Wang Y, Zhang Y, Li P-C, Guo J, Huo F, Yang J, Jia R, Wang J, Huang Q, <\/span>Theodorescu D*<\/strong>\n , Yu H*, Yan C*. <\/span>\n \n Development of Novel Aptamer-Based Targeted Chemotherapy for Bladder Cancer<\/u>\n <\/a>. Cancer Res. 2022;82(6):1128-39. *Corresponding Authors
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Awards<\/h4>\n <\/div>\n <\/div>\n
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Received a<\/span>\n <\/u>\n \n National Cancer Institute R35 Outstanding Investigator Award<\/u>\n <\/a> to study loss of Y chromosome biology and investigate potential therapies for bladder cancer.

2023 American Urological Association (AUA) Presidential Citation. “For elucidating the molecular underpinnings of urothelial cancer”<\/span><\/h5>\n

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Peter Kuhn, PhD<\/h1>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n
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Recent Publications<\/h4>\n <\/div>\n <\/div>\n
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Higa N, Welter L, Xu L, Kolatkar A, Bramlett KS, Gjoerup OV, Graf R, Huang RSP, Leary RJ, Lee Y, Perkins J, Riker A, Singh A, Tafra L, Tweed C, Shriver C, Hicks J,<\/strong>\n Kuhn P<\/strong>. <\/strong>\n \n Liquid Biopsy Profiling with Multiple Tests in Patients with Metastatic Breast Cancer<\/u>\n <\/a>.<\/span> Journal of Molecular Pathology<\/em>. 2024; 5(2):199-214. https:\/\/doi.org\/10.3390\/jmp5020013<\/strong><\/p>\n

Welter L, Zheng S, Setayesh SM, Morikado M, Agrawal A, Nevarez R, Naghdloo A, Pore M, Higa N, Kolatkar A, Thiele JA, Sharma P, Moore H, Richer J, Elias A, Pienta K, Zurita A, Gross M, Shishido SN, Hicks J, Ruiz C, <\/span>\n Kuhn P<\/strong>. <\/span>\n \n Cell state and cell type: Deconvoluting circulating tumor cell populations in liquid biopsies by multi-omics<\/u>\n <\/a>\n .<\/u> Cancers. 2023, 15(15):3949.
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Setayesh S, Hart O, Naghdloo A, Higa N, Nieva J, Lu J, Hwang S, Wilkinson K, Kidd M, Anderson A, Velasco C, Kolatkar A, Matsumoto N, Nevarez R, Hicks J, Mason J, Shishido S, <\/span>\n Kuhn P<\/strong>. <\/span>\n \n Multianalyte Liquid Biopsy to Aid the Diagnostic Workup of Breast Cancer<\/u>\n <\/a>. npj Breast Cancer. 2022; 8(1):112
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Murgoitio-Esandi J, Tessone D, Naghdloo A, Shishido SN, Zhang B, Xu H, Dasgupta A, Mason J, Nagaraju RM, Courcoubetis G, Hicks J, Kuhn P<\/strong>, Oberai AA. \n \n Unsupervised detection of rare events in liquid biopsy assays<\/u>\n <\/a>. npjPrecis Oncol. 2025 Jul 5;9(1):225. doi: 10.1038\/s41698-025-01015-3. PMID: 40617936.<\/p>\n <\/div>\n <\/div>\n

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Awards<\/h4>\n <\/div>\n <\/div>\n
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Class of 2024 of National Academy of Inventors Senior Members <\/span>\n
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Robert Kortum, MD, PhD<\/span><\/h1>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n
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Recent Publications<\/span><\/h4>\n <\/div>\n <\/div>\n
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Daley BR, Theard PL, Hughes JM, Finniff BA, Hofmann MA, Kostyrko K, Schenk RL, Vieira HM, Askew JW, Lewis RE, and <\/span>Kortum RL<\/strong> (2025). SOS1 inhibition targets the evolution of osimertinib resistance to generate a durable response in <\/span>\n EGFR<\/em>-mutated lung cancer. <\/span>Science Signaling,<\/em> <\/span>18:<\/strong>\n aea2788, <\/span>in press<\/em>. <\/span><\/p>\n

Sealover NE, Finniff BA, Hughes JM, Sheffels E, Lee H, LaMorte JP, Gambhir V, Beckley Z, Linke A, Wilkerson MD, Yohe ME, and <\/span>Kortum RL<\/strong>\n (2025). <\/span>\n \n Wild-type RAS signaling is an essential therapeutic target in <\/u>RAS<\/u><\/em>\n -mutated cancers<\/u>\n <\/a>. <\/span>Science Signaling,<\/em> <\/span>18:<\/strong>eadx5186. PMID:40956876<\/span><\/p>\n

Daley BR, Sealover NE, Finniff BA, Hughes JM, Sheffels E, Gerlach D, Hofmann MH, Kostyrko K, LaMorte JP, Linke AJ, Beckley Z, Frank AM, Lewis RE, Wilkerson MD, Dalgard CL, and <\/span>\n Kortum RL <\/strong>(2025). <\/span>\n \n SOS1 Inhibition Enhances the Efficacy of KRASG12C Inhibitors and Delays Resistance in lung adenocarcinoma<\/u>\n <\/a>. <\/span>Cancer Research<\/em>, <\/span>85<\/strong>: 118-133. PMID:39437166<\/span><\/p>\n

Sealover NE, Theard PT, Linke AJ, Hughes JM, Daley BR, and <\/span>Kortum RL<\/strong> (2024). <\/span>\n \n In situ modeling of acquired resistance to RTK\/RAS pathway targeted therapies<\/u>\n <\/a>. <\/span>iScience<\/em>, <\/span>27<\/strong>:108711. PMID:38226159<\/span><\/p>\n

Daley BR, Vieira HM, Rao C, Hughes JM, Huisman DH, Chatterjee D, Sealover NE, Cox K, Askew JW, Beckley ZM, Svoboda RA, Fisher KW, Lewis RE, and <\/span>Kortum RL<\/strong>\n (2023). <\/span>\n \n SOS1 and KSR1 modulate MEK inhibitor responsiveness to target resistant cell populations based on PI3K and KRAS mutation status<\/u>\n <\/a>. <\/span>PNAS<\/em>, <\/span>120<\/strong>:e2313137120. PMID:37972068<\/span><\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n

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Stephen Pandol, MD<\/span><\/h1>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n
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Recent Publications<\/span><\/h4>\n <\/div>\n <\/div>\n
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Wang R, Park K, Gaddam S, Liu Q, Watson R, Lim A, Ou Y, Zhang Y, Edderkaoui M, Lewis MS, Lo SK, <\/span>Pandol SJ<\/strong>. <\/span>\n \n Significantly higher incidence of circulating fatty objects in portal blood samples compared to peripheral blood samples in patients with pancreatic ductal adenocarcinoma<\/u>\n <\/a>\n .<\/u> Front Oncol. 2025 Sep 2;15:1611872. doi: 10.3389\/fonc.2025.1611872. PMID: 40963865; PMCID: PMC12436445.<\/span><\/p>\n

Birtolo C, Pham H, Morvaridi S, Chheda C, Go VL, Ptasznik A, Edderkaoui M, Weisman MH, Noss E, Brenner MB, Larson B, Guindi M, Wang Q, <\/span>Pandol SJ<\/strong>\n . <\/span>\n \n Cadherin-11 Is a Cell Surface Marker Up-Regulated in Activated Pancreatic Stellate Cells and Is Involved in Pancreatic Cancer Cell Migration<\/u>\n <\/a>. Am J Pathol. 2017 Jan;187(1):146-155. doi: 10.1016\/j.ajpath.2016.09.012. Epub 2016 Nov 14. PMID: 27855278; PMCID: PMC5225304.<\/span><\/p>\n

Lugea, A., Tischler, D., Nguyen, J., Gong, J., Gukovsky, I., French, S.W., Gorelick, F.S., & <\/span>Pandol, S.J.<\/strong> (2011). <\/span>\n \n Adaptive unfolded protein response attenuates alcohol-induced pancreatic damage<\/u>\n <\/a>. <\/span>Gastroenterology<\/em><\/strong>, 140(3), 987-997. PMCID: PMC3057335<\/span><\/p>\n

Edderkaoui M, Nitsche C, Zheng L, <\/span>Pandol SJ<\/strong>, Gukovsky I, Gukovskaya AS. <\/span>\n \n NADPH oxidase activation in pancreatic cancer cells is mediated through Akt-dependent up-regulation of p22phox<\/u>\n <\/a>. J Biol Chem. 2011 Mar 11;286(10):7779-7787. doi: 10.1074\/jbc.M110.200063. Epub 2010 Nov 30. Erratum in: J Biol Chem. 2013 Dec 20;288(51):36259. doi: 10.1074\/jbc.A113.200063. PMID: 21118808; PMCID: PMC3048665.<\/span><\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"

CSVCC LEADERSHIP RESEARCH Dan Theodorescu, MD, PhD Recent Publications Chen X, Shen Y, Choi S, Abdel-Hafiz HA, Basu M, Hoelzen L, Tufano M, Kailasam Mani SK, Ranjpour M, Zhu J, Ramanujan VK, Koltsova EK, Calsavara VF, Knott SRV, Theodorescu D. Concurrent loss of the Y chromosome in cancer and T cells impacts outcome . Nature. […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":8068,"menu_order":3,"comment_status":"closed","ping_status":"closed","template":"page-templates\/full-width-page.php","meta":{"content-type":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"class_list":["post-8060","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/csvcc.org\/index.php?rest_route=\/wp\/v2\/pages\/8060","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/csvcc.org\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/csvcc.org\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/csvcc.org\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/csvcc.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=8060"}],"version-history":[{"count":20,"href":"https:\/\/csvcc.org\/index.php?rest_route=\/wp\/v2\/pages\/8060\/revisions"}],"predecessor-version":[{"id":14126,"href":"https:\/\/csvcc.org\/index.php?rest_route=\/wp\/v2\/pages\/8060\/revisions\/14126"}],"up":[{"embeddable":true,"href":"https:\/\/csvcc.org\/index.php?rest_route=\/wp\/v2\/pages\/8068"}],"wp:attachment":[{"href":"https:\/\/csvcc.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=8060"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}