{"id":28,"date":"2021-05-26T19:40:42","date_gmt":"2021-05-27T02:40:42","guid":{"rendered":"https:\/\/csvcc.org\/?page_id=28"},"modified":"2025-09-02T14:25:30","modified_gmt":"2025-09-02T21:25:30","slug":"research","status":"publish","type":"page","link":"https:\/\/csvcc.org\/?page_id=28","title":{"rendered":"Scholars Research – Cohort 1"},"content":{"rendered":"
\n \n
\n \n \n
\n \n
\n \n
\n \n
\n
\n \n \n
\n \n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n
\n \n \n
\n \n
\n \n
\n \n
\n
\n \n \n
\n \n
\n \n
\n \n \n

COHORT 1<\/h1>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n
\n \n
\n \n
\n
\n \n \n
\n \n
\n \n
\n
\n \n \n \"\"\n
<\/div>\n <\/div>\n <\/div>\n <\/div>\n
\n \n
\n \n \n

Peiwen Chen, PhD<\/h1>\n <\/div>\n <\/div>\n
\n \n
\n \n
\n
\n \n \n
\n \n
\n \n
\n \n \n

Project<\/h2>\n <\/div>\n <\/div>\n
\n \n \n
\n

Mechanism and Therapeutic Potential of PTEN-Regulated MDSCc in Glioblastoma<\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n

\n
\n \n \n
\n \n
\n \n
\n \n \n

Topic Area<\/h2>\n <\/div>\n <\/div>\n
\n \n \n
\n

Brain Cancer<\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n

\n
\n \n \n
\n \n
\n \n <\/div>\n
\n \n
\n \n \n

Highlighted Publications<\/h3>\n <\/div>\n <\/div>\n
\n \n \n
\n

Khan F, Pang L, Dunterman M, Lesniak MS, Heimberger AB, Chen P<\/strong>.\n \n Macrophages and Microglia in Glioblastoma: Hetergeneity, Plasticity, and Therapy<\/u>\n <\/a>. Journal of Clinical Investigation. 2023. 133(1):e163446. **CSVCC Supported**<\/strong><\/p>\n

Pang L, Dunterman M, Xuan W, Gonzalez A, Lin Y, Hsu W, Khan F, Hagan R, Muller W, Heimberger A, Chen P<\/strong>.\n \n Circadian Regulator CLOCK Promotes Tumor Angiogenesis in Glioblastoma<\/u>\n <\/a>. Cell Reports. 2023; 42(2): 112127. **CSVCC Supported**<\/strong><\/p>\n

Khan F, Lin Y, Ali H, Pang L, Dunterman M, Hsu WH, Frenis K, Rowe RG, Wainwright D, McCortney K, Billingham L, Miska J, Horbinski C, Lesniak M, Chen P<\/strong>.\n \n Lactate Dehydrogenase A Regulates<\/u> <\/u><\/strong>\n Tumor-Macrophage Symbiosis to Promote Glioblastoma Progression<\/u>\n <\/a>. Nature Communications. 15, 1987 (2024). **CSVCC Supported**<\/strong><\/p>\n

Liu Y, Pang L, Khan F, Wu J, Zhou F, Horbinski C, Bao S, Yu JS, Lathia JD, <\/span>Chen P<\/strong>\n . <\/span>\n \n Glycoprotein NMB mediates bidirectional GSC-TAM interactions to promote tumor progression<\/u>\n <\/a>. JCI Insight. 2025 Jul 8;10(13):e187684. doi: 10.1172\/jci.insight.187684. PMID: 40626360.<\/span> **CSVCC Supported**<\/strong><\/p>\n

Khan F, Liu Y, Whitfield D, Pang L, Ali H, Huang Y, Zhou F, Hagan RS, Frenis K, <\/span>Rowe RG<\/strong>, <\/span>\n Chen P<\/strong>. <\/span>\n \n Macrophage TBK1 signaling drives the development and outgrowth of breast cancer brain metastasis<\/u>\n <\/a>. Proc Natl Acad Sci U S A. 2025 Aug 26;122(34):e2420793122. doi: 10.1073\/pnas.2420793122. Epub 2025 Aug 20. PMID: 40833415. <\/span>\n **CSVCC Supported**<\/strong>\n <\/p>\n

<\/span><\/p>\n

<\/span><\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n

\n \n \n
\n \n
\n \n
\n \n
\n
\n \n \n
\n \n
\n \n
\n
\n \n \n \"\"\n
<\/div>\n <\/div>\n <\/div>\n <\/div>\n
\n \n
\n \n \n

Dalnim Cho, PhD<\/h1>\n <\/div>\n <\/div>\n
\n \n
\n \n
\n
\n \n \n
\n \n
\n \n
\n \n \n

Project<\/h2>\n <\/div>\n <\/div>\n
\n \n \n
\n

Trajectories of Adjustment in Young Adult Cancer Patient-Caregiver Dyads: A Measurement Burst Study to Examine Short- and Long-Term Change and Variability<\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n

\n
\n \n \n
\n \n
\n \n
\n \n \n

Topic Area<\/h2>\n <\/div>\n <\/div>\n
\n \n \n
\n

Pediatric, Adolescent, and Young Adult Cancers<\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n

\n
\n \n \n
\n \n
\n \n
\n \n \n

Highlighted Publications<\/h2>\n <\/div>\n <\/div>\n
\n \n \n
\n

Cho D<\/strong>, Kim S, Durrani S, Liao Z, Milbury K. <\/span>\n \n Associations Between Spirituality, Mindfulness, and Psychological Symptoms Among Advanced Lung Cancer Patients and Their Spousal Caregivers<\/u>\n <\/a>. Journal of Pain and Symptom Management. 2021;61(5):898-908.e1.<\/span><\/p>\n

Cho D<\/strong>, Milbury K, Liao Y, Pettaway CA, Gregg JR, Li Y, McNeill LH. <\/span>\n \n Study Protocol: One Plus One Can Be Greater Than Two\u2014Ecological Momentary Assessment for Black Prostate Cancer Survivors and Partners<\/u>\n <\/a>. PLoS One. 2021;16(8):e0255614.<\/span><\/p>\n

Kroll JL, Kim S, <\/span>Cho D<\/strong>, Weathers S-P, Chen AB, Smith G, Bruera E, Milbury K.<\/span>\n <\/u>\n \n Financial Distress and Its Associated Burden in Couples Coping with an Advanced Cancer<\/u>\n <\/a>\n .<\/u> Support Care Cancer. 2022;30(5): 4485-95.<\/span><\/p>\n

Cho D<\/strong>, Roth M, Peterson SK, Jennings K, Kim S, Weathers SP, Ahmed S, Livingston JA, Barcenas C, You YN, Milbury K. <\/span>\n \n Associations Between Stress, Health Behaviors, and Quality of Life in Young Couples During the Transition to Survivorship: Protocol for a Measurement Burst Study<\/u>\n <\/a>. JMIR Res Protoc 2024;13:e53307. <\/span>**CSVCC Supported*<\/strong>*<\/span><\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n

\n \n \n
\n \n
\n \n
\n \n
\n
\n \n \n
\n \n
\n \n
\n
\n \n \n \"\"\n
<\/div>\n <\/div>\n <\/div>\n <\/div>\n
\n \n
\n \n \n

Abby Green, MD<\/h1>\n <\/div>\n <\/div>\n
\n \n
\n \n
\n
\n \n \n
\n \n
\n \n
\n \n \n

Project<\/h1>\n <\/div>\n <\/div>\n
\n \n \n
\n

Mutagenic Deaminase Activity in Cancer<\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n

\n
\n \n \n
\n \n
\n \n
\n \n \n

Topic Area<\/h2>\n <\/div>\n <\/div>\n
\n \n \n
\n

Blood Cancers<\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n

\n
\n \n \n
\n \n
\n \n
\n \n \n

Highlighted Publications<\/h1>\n <\/div>\n <\/div>\n
\n \n \n
\n

Mathias B, O\u2019Leary D, Saucier N, Ahmad F, White L, Russell L, Shinawi M, Smith M, Abraham R, Cooper M, Kitcharoensakkul M, Green A<\/strong>, Bednarski J.\n <\/u>\n \n MYSM1 Attenuates DNA Damage Signals Triggered by Physiologic and Genotoxic DNA Breaks<\/u>\n <\/a>. J Allergy Clin Immunol. 2024 Apr;153(4):1113-1124.e7. Epub 2023 Dec 6. **CSVCC Supported**<\/strong><\/p>\n

Fingerman D, O’Leary D, Hansen A, Tran T, Harris B, DeWeerd R, Hayer K, Fan J, Chen E, Tennakoon M, Meroni A, Szeto J, Devenport J, LaVigne D, Weitzman M, Shalem O, Bednarski J, Vindigni A, Zhao X, Green A.\n \n The SMC5\/6 Complex Prevents Genotoxicity Upon APOBEC3A-Mediated Replication Stress<\/u>\n <\/a>.<\/span> EMBO J. 2024 Jun 17. doi: 10.1038\/s44318-024-00137-x. Epub ahead of print. PMID: 38886582.<\/span> **CSVCC Supported**<\/strong><\/p>\n

Devenport J, Tran T, Harris B, Fingerman D, DeWeerd R, Elkhidir L, LaVigne D, Fuh K, Sun L, Bednarski J, Drapkin R, Mullen M, Green A. <\/strong>\n \n APOBEC3A Drives Ovarian Cancer Metastasis by<\/u>\n <\/a>\n \n <\/u>\n <\/a>\n \n Altering Epithelial<\/u>\n <\/a>\n \n –<\/u>\n <\/a>\n \n Mesenchymal Transition<\/u>\n <\/a>. JCI Insight. 2025 Mar 10;10(5):e186409. PMID40059825; PMCID: PMC11949045. **CSVCC Supported**<\/strong><\/p>\n

Ortega P, Bournique E, Li J, Sanchez A, Santiago G, Harris B, Striepen J, Maciejowski J, Green A<\/strong>, Buisson R. \n \n Mechanism of DNA Replication Fork Breakage and PARP1 Hyperactivation During Replication Catastrophe<\/u>\n <\/a>. Sci Adv. 2025 Apr 18;11(16):eadu0437. PMID40238882. **CSVCC Supported**<\/strong><\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n

\n \n \n
\n \n
\n \n
\n \n
\n
\n \n \n
\n \n
\n \n
\n
\n \n \n \"\"\n
<\/div>\n <\/div>\n <\/div>\n <\/div>\n
\n \n
\n \n \n

Berkley Gryder, PhD<\/h1>\n <\/div>\n <\/div>\n
\n \n
\n \n
\n
\n \n \n
\n \n
\n \n
\n \n \n

Project<\/h1>\n <\/div>\n <\/div>\n
\n \n \n
\n

Therapeutically Targeting Superclusters at Genes Driving Childhood Sarcoma<\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n

\n
\n \n \n
\n \n
\n \n
\n \n \n

Topic Area<\/h1>\n <\/div>\n <\/div>\n
\n \n \n
\n

Pediatric, Adolescent, and Young Adult Cancers<\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n

\n
\n \n \n
\n \n
\n \n
\n \n \n

Highlighted Publications<\/h1>\n <\/div>\n <\/div>\n
\n \n \n
\n

Chin D, Osman I, Porch J, Kim H, Buck K, Rodriguez J, Carapia B, Yan D, Moura S, Sperry J, Nakashima J, Altman K, Altman D, <\/span>Gryder B<\/strong>. <\/span>\n \n BET Bromodomain Degradation Disrupts Function but Not 3D Formation of RNA Pol2 Clusters. Pharmaceuticals<\/u>\n <\/a>. 2023; 16(2), 199. <\/span>**CSVCC Supported**<\/strong><\/p>\n

\ufeff<\/strong>Banerjee D, Bagchi S, Liu Z, Chou HC, Xu M, Sun M, Aloisi S, Vaksman Z, Diskin S, Zimmerman M, Khan J, <\/span>\n Gryder B<\/strong>, Thiele C. <\/span>\n \n Lineage specific transcription factor waves reprogram neuroblastoma from self-renewal to differentiation<\/u>\n <\/a>. Nat Commun 15, 3432 (2024).<\/span> <\/span>**CSVCC Supported**<\/strong>\n \n
\n <\/span>\n <\/p>\n <\/div>\n <\/div>\n

\n \n
\n \n \n

Updates<\/h1>\n <\/div>\n <\/div>\n
\n \n \n
\n

\n Awarded a grant related to his CSVCC work. Importantly, it is from the family of a young lady still battling this disease, and they are experimenting on her very own tumor cells. This $54k grant will expand the identification of\n new strategies to therapeutically intervene for rhabdomyosarcomas (RMS) driven by PAX3-FOXO1 and MYCN and treat cells with different drugs, at a variety of concentrations, in order to determine how potent they are against RMS cell\n lines.<\/a>\n <\/p>\n

\n Presented work at the AACR Special Conference (May 9-12, 2022) and was selected for a public talk: \u201cThe 3D epigenome of rhabdomyosarcoma.\u201d<\/a>\n <\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n

\n \n \n
\n \n
\n \n
\n \n
\n
\n \n \n
\n \n
\n \n
\n
\n \n \n \"\"\n
<\/div>\n <\/div>\n <\/div>\n <\/div>\n
\n \n
\n \n \n

Hae Lin Jang, PhD<\/h1>\n <\/div>\n <\/div>\n
\n \n
\n \n
\n
\n \n \n
\n \n
\n \n
\n \n \n

Project<\/h1>\n <\/div>\n <\/div>\n
\n \n \n
\n

Developing Novel Immunotherapy to Suppress Cancer Metastasis and Recurrence in Bone<\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n

\n
\n \n \n
\n \n
\n \n
\n \n \n

Topic Area<\/h1>\n <\/div>\n <\/div>\n
\n \n \n
\n

Metastatic Cancers<\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n

\n
\n \n \n
\n \n
\n \n
\n \n \n

Highlighted Publications<\/h1>\n <\/div>\n <\/div>\n
\n \n \n
\n

Ghosh S, Sinha M, Samanta R, Sadhasivam S, Bhattacharyya A, Nandy A, Saini S, Tandon N, Singh H, Gupta S, Chauhan A, Aavula KK, Varghese SS, Shi P, Ghosh S, Garg MK, Saha T, Padhye A, Gosh S*, <\/span>\n Jang HL*<\/strong>, Sengupta S*. <\/span>\n \n A potent antibiotic-loaded bone-cement implant against staphylococcal bone infections<\/u>\n <\/a>. Nature Biomedical Eng. 2022;6:1180-95. <\/span><\/p>\n

Saha T, Dash C, Jayabalan R, Khiste S, Kulkarni A, Kurmi K, Mondal J, Majumder P, Bardia A, <\/span>Jang HL<\/strong>\n , Sengupta S. <\/span>\n \n Intercellular nanotubes mediate mitochondrial trafficking between cancer and immune cells<\/u>\n <\/a>\n .<\/u> Nat. Nanotechnol. 2022;17(1):98-106. <\/span>**CSVCC Supported**<\/strong>
<\/span><\/p>\n

Lee V, Lee T, Ghosh A, Saha T, Bais M, Bharani K, Chag M, Parikh K, Bhatt P, Namgung B, Venkataramanan G, Agrawal A, Sonaje K, Mavely L, <\/span>Sengupta S<\/strong>\n , Mashelkar R, <\/span>Jang HL<\/strong>. <\/span>\n \n An Architecturally Rational Hemostat for Rapid Stopping of Massive Bleeding on Anticoagulation Therapy<\/u>\n <\/a>. Proc Natl Acad Sci USA. 2024 Jan 30;121(5):e2316170121. Epub 2024 Jan 2022. <\/span>**CSVCC Supported**<\/strong><\/p>\n

Saha T, Fojtu M, Nagar A, Thurakkal L, Srinivasan B, Mukherjee M, Sibiyon A, Aggarwal H, Samuel A, Dash C, <\/span>Jang HL<\/strong>, Sengupta S. <\/span>\n \n Antibody Nanoparticle Conjugate-Based Targeted Immunotherapy for Non-Small Lung Cancer<\/u>\n <\/a>. Sci Adv. <\/span>2024 Jun 14;10(24):eadi2046. doi: 10.1126\/sciadv.adi2046. Epub 2024 Jun 14. PMID: 38875335; PMCID: PMC11177938. <\/span>\n **CSVCC Supported**<\/strong>
<\/span><\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n

\n \n \n
\n \n
\n \n
\n \n
\n
\n \n \n
\n \n
\n \n
\n
\n \n \n \"\"\n
<\/div>\n <\/div>\n <\/div>\n <\/div>\n
\n \n
\n \n \n

Robert G. Rowe, MD, PhD<\/h1>\n <\/div>\n <\/div>\n
\n \n
\n \n
\n
\n \n \n
\n \n
\n \n
\n \n \n

Project<\/h1>\n <\/div>\n <\/div>\n
\n \n \n
\n

Defining Leukemia Stem Cell in Acute Lymphoblastic Leukemia<\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n

\n
\n \n \n
\n \n
\n \n
\n \n \n

Topic Area<\/h1>\n <\/div>\n <\/div>\n
\n \n \n
\n

Blood Cancers<\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n

\n
\n \n \n
\n \n
\n \n
\n \n \n

Highlighted Publications<\/h1>\n <\/div>\n <\/div>\n
\n \n \n
\n

Khan F, Liu Y, Whitfield D, Pang L, Ali H, Huang Y, Zhou F, Hagan RS, Frenis K, <\/span>Rowe RG<\/strong>, <\/span>\n Chen P<\/span>. <\/span>\n Macrophage TBK1 signaling drives the development and outgrowth of breast cancer brain metastasis<\/a>. Proc Natl Acad Sci U S A. 2025 Aug 26;122(34):e2420793122. doi: 10.1073\/pnas.2420793122. Epub 2025 Aug 20. PMID: 40833415. <\/span>\n **CSVCC Supported**<\/strong>\n <\/p>\n

Morris V, Wang D, Li Z, Marion W, Hughes T, Sousa P, Harada T, Sui SH, Naumenko S, Kalfon J, Sensharma P, Falchetti M, da Silva RV, Candelli T, Schnieder P, Margaritis T, Holstege FCP, Pikman Y, Harris M, Stam RW, Orkin SH, Koehler AN, Shalek AK, North TE, Pimkin M, Daley GQ, da Rocha EL, <\/span>Rowe RG<\/strong>.\n \n Hypoxic, Glycolytic Metabolism is a Vulnerability of B-Acute Lymphoblastic Leukemia-Initiating Cells<\/u>\n <\/a>.<\/span> Cell Reports. 2022;39(4):110752. **CSVCC Supported**<\/strong>\n
\n <\/p>\n

Chen CC, Silberman R, Ma D, Perry J, Khalid D, Pikman Y, Amon A, Hemann M,<\/span> Rowe RG.<\/strong>\n <\/span>\n \n Inherent Genome Instability Underlies Trisomy 21-Associated Myeloid Malignancies<\/u>\n <\/a>. Leukemia. 2024 38(3):521-529. <\/span><\/p>\n

Li Z, Fierstein S, Tanaka-Yano M, Frenis K, Chen CC, Wang D, Falchetti M, Cote P, Curran C, Lu K, Liu T, Orkin S, Li H, Lummertz da Rocha E, Hu S, Zhu Q, <\/span>\n Rowe RG<\/strong>. <\/span>\n \n The Epigenetic State of the Cell of Origin Defines Mechanisms of Leukemogenesis<\/u>\n <\/a>. Leukemia. 2024 Oct 1. Epub ahead of print. <\/span>**CSVCC Supported**<\/strong>\n \n
\n <\/span>\n <\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n

\n \n \n
\n \n
\n \n
\n \n
\n
\n \n \n
\n \n
\n \n
\n
\n \n \n \"\"\n
<\/div>\n <\/div>\n <\/div>\n <\/div>\n
\n \n
\n \n \n

Nilay Sethi, MD, PhD<\/h1>\n <\/div>\n <\/div>\n
\n \n
\n \n
\n
\n \n \n
\n \n
\n \n
\n \n \n

Project<\/h1>\n <\/div>\n <\/div>\n
\n \n \n
\n

Determining the Molecular Basis and Therapeutic Potential of Hyperactive Stem Cell Programs in Colorectal Cancer<\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n

\n
\n \n \n
\n \n
\n \n
\n \n \n

Topic Area<\/h1>\n <\/div>\n <\/div>\n
\n \n \n
\n

Colorectal Cancer<\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n

\n
\n \n \n
\n \n
\n \n
\n \n \n

Highlighted Publications<\/h1>\n <\/div>\n <\/div>\n
\n \n \n
\n

Duronio GN, Liang X, Hebbar P, Islam M, Spisak S, <\/span>Sethi NS.<\/strong>\n <\/span>\n \n Truncating SOX9 Alterations are Heterozygous Null Alleles in Genome Stable Colorectal Cancer.<\/u>\n <\/a>\n <\/u>Gastro Hep Advances. 2022; 1(5):709-13. <\/span>**CSVCC Supported**<\/strong>\n \n
\n <\/span>\n <\/p>\n

Bala P, Rennhack J, Aitymbayev D, Morris C, Moyer S, Duronio G, Doan P, Li Z, Liang X, Hornick J, Yurgelun M, Hahn W, Sethi N<\/strong>. <\/span>\n \n Aberrant Cell State Plasticity Mediated by Developmental Reprogramming Precedes Colorectal Cancer Initiation<\/u>\n <\/a>.<\/span> Science Advances. 2023; 9(13):eadf0927. *CSVCC Supported*<\/strong><\/p>\n

Spisak S, Chen D, Likasitwatanakul P, Doan P, Li Z, Bala P, Vizkeleti L, Tisza V, De Silva P, Giannakis M, Wolpin B, Qi J, Sethi N. <\/strong>\n \n Identifying Regulators of Aberrant Stem Cell and Differentiation Activity in Colorectal Cancer Using a Dual Endogenous Reporter System<\/u>\n <\/a>.<\/span> Nature Communications. 2024 12;15(1):2230. **CSVCC Supported**<\/strong><\/p>\n

Likasitwatanakul P, Li Z, Doan P, Spisak S, Raghawan AK, Liu Q, LiowP, Lee S, Chen D, Bala P, Sahgal P, Aitymbayev D, Thalappillil JS, Papanastasiou M, Hawkins W,Carr SA, Park H, Cleary JM, Qi J, Sethi NS<\/strong>.\n \n Chemical perturbations impacting histone acetylationgovern colorectal cancer differentiation<\/u>\n <\/a>\n .<\/u> Gastroenterology (2025), doi: https:\/\/doi.org\/10.1053\/j.gastro.2025.07.003. <\/span>**CSVCC Supported**<\/strong><\/p>\n


<\/strong><\/p>\n <\/div>\n <\/div>\n

\n \n
\n \n \n

Patents<\/h1>\n <\/div>\n <\/div>\n
\n \n \n
\n

Compositions and Methods for Treating and\/or Identifying an Agent for Treating Intestinal Cancer\ufeff<\/span><\/span>\n <\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n

\n \n \n
\n \n
\n \n
\n \n
\n
\n \n \n
\n \n
\n \n
\n
\n \n \n \"\"\n
<\/div>\n <\/div>\n <\/div>\n <\/div>\n
\n \n
\n \n \n

Min Xue, PhD<\/h1>\n <\/div>\n <\/div>\n
\n \n
\n \n
\n
\n \n \n
\n \n
\n \n
\n \n \n

Project<\/h1>\n <\/div>\n <\/div>\n
\n \n \n
\n

Multicyclic Peptide-Based Protein-Protein Interaction Modulators for Inhibiting Oncogenic MYC Activities<\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n

\n
\n \n \n
\n \n
\n \n
\n \n \n

Topic Area<\/h1>\n <\/div>\n <\/div>\n
\n \n \n
\n

Brain Cancer<\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n

\n
\n \n \n
\n \n
\n \n
\n \n \n

Highlighted Publications<\/h1>\n <\/div>\n <\/div>\n
\n \n \n
\n

Guo Z, Cheng H, Li Z, Shao S, Sarkar P, Wang S, Chaudhuri R, Perkins N, Ji F, Wei W, <\/span>Xue M. <\/strong>\n \n Single-Cell Profiling of Fatty Acid Uptake Using Surface-Immobilized Dendrimers<\/u>\n <\/a>. Journal of the American Chemical Society. 2021; 143(29):11191-11198.<\/span><\/p>\n

Wang S, Li Z, Aispuro D, Guevara N, Van Valkenburgh J, Chen B, Zhou X, McCarroll M, Ji F, Cong X, Sarkar P, Chaudhuri R, Guo Z, Perkins N, Shao S, Sello J, Chen K, <\/span>Xue M. <\/strong>\n \n Hydroxyl-Rich Hydrophilic Endocytosis-Promoting Peptide with No Positive Charge<\/u>\n <\/a>\n .<\/u> Journal of the American Chemical Society. 2022; 144(44):20288-20297. <\/span>**CSVCC Supported**<\/strong><\/p>\n

Li F, Hur M, Mur S, Wang S, Sarkar P, Shao S, Aispuro D, Cong X, Hu Y, Li Z<\/span>, Xue M. <\/strong>\n \n Multiplex Protein Imaging through PACIFIC: Photoactive Immunofluorescence with Iterative Cleavage<\/u>\n <\/a>.<\/span> ASC Bio & Med Chem. 2023; doi.org\/10.1021\/acsbiomedchemau.3c00018<\/span><\/p>\n

Li Z, Huang Y, Hung T, Sun J, Aispuro D, Chen B, Guevara N, Ji F, Cong X, Zhu L, Wang S, Guo Z, Chang C, Xue M. <\/span>\n \n MYC-Targeting Inhibitors Generated from a Stereodiversified Bicyclic Peptide Library<\/u>\n <\/a>. J. Am. Chem. Soc. 2024, 146, 2, 1356-1363. <\/span>**CSVCC Supported**<\/strong>
<\/span><\/p>\n <\/div>\n <\/div>\n

\n \n
\n \n \n

Updates<\/h1>\n <\/div>\n <\/div>\n
\n \n \n
\n

Gave an invited talk at the ASBMB annual meeting this April, as part of the “Chemical Biology Focus Group.” The title was “Chemical Biology Applications of Cyclic peptides.”<\/span><\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"

COHORT 1 Peiwen Chen, PhD Project Mechanism and Therapeutic Potential of PTEN-Regulated MDSCc in Glioblastoma Topic Area Brain Cancer Highlighted Publications Khan F, Pang L, Dunterman M, Lesniak MS, Heimberger AB, Chen P. Macrophages and Microglia in Glioblastoma: Hetergeneity, Plasticity, and Therapy . Journal of Clinical Investigation. 2023. 133(1):e163446. **CSVCC Supported** Pang L, Dunterman M, […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":8068,"menu_order":3,"comment_status":"closed","ping_status":"closed","template":"page-templates\/full-width-page.php","meta":{"content-type":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"class_list":["post-28","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/csvcc.org\/index.php?rest_route=\/wp\/v2\/pages\/28","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/csvcc.org\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/csvcc.org\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/csvcc.org\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/csvcc.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=28"}],"version-history":[{"count":20,"href":"https:\/\/csvcc.org\/index.php?rest_route=\/wp\/v2\/pages\/28\/revisions"}],"predecessor-version":[{"id":13923,"href":"https:\/\/csvcc.org\/index.php?rest_route=\/wp\/v2\/pages\/28\/revisions\/13923"}],"up":[{"embeddable":true,"href":"https:\/\/csvcc.org\/index.php?rest_route=\/wp\/v2\/pages\/8068"}],"wp:attachment":[{"href":"https:\/\/csvcc.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=28"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}