{"id":14839,"date":"2026-06-18T16:52:25","date_gmt":"2026-06-18T23:52:25","guid":{"rendered":"https:\/\/csvcc.org\/?page_id=14839"},"modified":"2026-06-19T11:16:05","modified_gmt":"2026-06-19T18:16:05","slug":"scholars-research-cohort-4","status":"publish","type":"page","link":"https:\/\/csvcc.org\/?page_id=14839","title":{"rendered":"— Scholars Research – Cohort 4"},"content":{"rendered":"
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COHORT4<\/h1>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n
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Erik Blomain, MD, PhD<\/span><\/h1>\n <\/div>\n <\/div>\n
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Project<\/span><\/h2>\n <\/div>\n <\/div>\n
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Chemoradiation Imparts KRAS-Mediated Resistance to Immunotherapy in Non-Small Cell Lung Cancer<\/span><\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n

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Topic Area<\/span><\/h2>\n <\/div>\n <\/div>\n
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Lung Cancer<\/span><\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n

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Highlighted Publications<\/span><\/h3>\n <\/div>\n <\/div>\n
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Blomain ES<\/strong>, Soudi S, Wang Z, Somani A, Subramanian A, Nouth SCL, Oladipo E, New C, Kenney DE, Nemat-Gorgani N, Kindler T, Avedian RS, Steffner RJ, Mohler DG, Hiniker SM, Chin AL, Kalbasi A, Binkley MS, Fried M, Gaida MM, van de Rijn M, Moding EJ. <\/span>\n \n Evolutionary Pressures Shape Undifferentiated Pleomorphic Sarcoma Development and Radiotherapy Response<\/u>\n <\/a>. Cancer Res. 2025 Mar 14;85(6):1162-1174. doi: 10.1158\/0008-5472.CAN-24-3281. PMID: 39808162; PMCID: PMC13007602.<\/span><\/p>\n

Blomain ES<\/strong>, Moding EJ. <\/span>\n \n Liquid Biopsies for Molecular Biology-Based Radiotherapy<\/u>\n <\/a>. Int J Mol Sci. 2021 Oct 19;22(20):11267. doi: 10.3390\/ijms222011267. PMID: 34681925; PMCID: PMC8538046.<\/span><\/p>\n

Blomain ES<\/strong>, Rappaport JA, Pattison AM, Bashir B, Caparosa E, Stem J, Snook AE, Waldman SA. <\/span>\n \n APC-\u03b2-catenin-TCF signaling silences the intestinal guanylin-GUCY2C tumor suppressor axis<\/u>\n <\/a>. Cancer Biol Ther. 2020 May 3;21(5):441-451. doi: 10.1080\/15384047.2020.1721262. Epub 2020 Feb 9. PMID: 32037952; PMCID: PMC7515458.<\/span><\/p>\n

Le K, <\/span>Blomain ES<\/strong>\n , Rodeck U, Aplin AE. <\/span>\n \n Selective RAF inhibitor impairs ERK1\/2 phosphorylation and growth in mutant NRAS, vemurafenib-resistant melanoma cells<\/u>\n <\/a>. Pigment Cell Melanoma Res. 2013 Jul;26(4):509-17. doi: 10.1111\/pcmr.12092. Epub 2013 Apr 8. PMID: 23490205; PMCID: PMC3695051.<\/span><\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n

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Matthew Gallitto, MD, PhD<\/span><\/h1>\n <\/div>\n <\/div>\n
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Optimization of Targeted Drug Delivery and Radiosensitizing Strategies for Pediatric Diffuse Midline Glioma<\/span><\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n

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Topic Area<\/span><\/h2>\n <\/div>\n <\/div>\n
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Brain Cancer<\/span><\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n

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Highlighted Publications<\/span><\/h3>\n <\/div>\n <\/div>\n
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Gallitto M<\/span>, Zhang X, De Los Santos G, Wei HJ, Fern\u00e1ndez EC, Duan S, Sedor G, Yoh N, Kokossis D, Angel JC, Wang YF, White E, Kinslow CJ, Berg X, Tomassoni L, Zandkarimi F, Chio IIC, Canoll P, Bruce JN, Feldstein NA, Gartrell RD, Cheng SK, Garvin JH, Zacharoulis S, Wechsler-Reya RJ, Pavisic J, Califano A, Zhang Z, Wu CC. <\/span>\n \n Targeted delivery of napabucasin with radiotherapy improves outcomes in diffuse midline glioma<\/u>\n <\/a>. Neuro Oncol. 2025 Mar 7;27(3):795-810. doi: 10.1093\/neuonc\/noae215. PMID: 39394920; PMCID: PMC11889722.<\/span><\/p>\n

Calvo Fern\u00e1ndez E, Tomassoni L, Zhang X, Wang J, Obradovic A, Laise P, Griffin AT, Vlahos L, Minns HE, Morales DV, Simmons C, <\/span>\n Gallitto M<\/span>, Wei HJ, Martins TJ, Becker PS, Crawford JR, Tzaridis T, Wechsler-Reya RJ, Garvin J, Gartrell RD, Szalontay L, Zacharoulis S, Wu CC, Zhang Z, Califano A, Pavisic J. <\/span>\n \n Systematic design of combination therapy by targeting master regulators of coexisting diffuse midline glioma cell state<\/u>s<\/a>. Nat Genet. 2026 May;58(5):1112-1125. doi: 10.1038\/s41588-026-02550-w. Epub 2026 Apr 22. PMID: 42020604; PMCID: PMC13175895.<\/span><\/p>\n

Zhang X, Duan S, Apostolou PE, Wu X, Watanabe J, <\/span>Gallitto M<\/span>\n , Barron T, Taylor KR, Woo PJ, Hua X, Zhou H, Wei HJ, McQuillan N, Kang KD, Friedman GK, Canoll PD, Chang K, Wu CC, Hashizume R, Vakoc CR, Monje M, McKhann GM 2nd, Gogos JA, Zhang Z. <\/span>\n \n CHD2 Regulates Neuron-Glioma Interactions in Pediatric Glioma<\/u>\n <\/a>. Cancer Discov. 2024 Sep 4;14(9):1732-1754. doi: 10.1158\/2159-8290.CD-23-0012. PMID: 38767413; PMCID: PMC11456263.<\/span><\/p>\n

Wu CC, Szalontay L, Pouliopoulos AN, Bae S, Berg X, Wei HJ, Webster Carrion A, Kokossis D, Sethi C, Fino J, Shatravka H, Lipina J, Ji R, Liu K, Yousefian O, <\/span>\n Gallitto M<\/span>, Yoh N, Englander Z, McQuillan N, Tazhibi M, De Los Santos G, Canoll P, Jin Z, Garvin J, Gartrell RD, Pavisic J, Maddocks A, Lignelli A, Feldstein N, Konofagou EE, Zacharoulis S. <\/span>\n \n Blood-brain barrier opening with neuronavigation-guided focused ultrasound in pediatric patients with diffuse midline glioma<\/u>\n <\/a>. Sci Transl Med. 2025 Nov 12;17(824):eadq6645. doi: 10.1126\/scitranslmed.adq6645. Epub 2025 Nov 12. PMID: 41223245.<\/span><\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n

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Lior Goldberg, MD, MS<\/span><\/h1>\n <\/a>\n <\/div>\n <\/div>\n
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Development of LRRC15-Targeted CAR T Cell Therapy for Osteosarcoma <\/span><\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n

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Sarcoma<\/span><\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n

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Goldberg L<\/span>, Haas ER, Wu J, Garcia B, Urak R, Vyas V, Espinosa R, Munoz T, Bierkatz S, Pathak KV, Hansen NP, Pirrotte P, Singhal J, Figarola JL, Noriega RZ, Li Z, Wi D, Tanaka E, Geltink RK, Chen MH, Wu X, Wagner JR, Paul J, Clark MC, Ngo D, Aldoss I, Forman SJ, Wang X. <\/span>\n \n Immunometabolic determinants of long-term response in leukemia patients receiving CD19 CAR T cell therapy<\/u>\n <\/a>. Nat Commun. 2026 Feb 20;17(1):2967. doi: 10.1038\/s41467-026-69857-4. PMID: 41720802; PMCID: PMC13035890.<\/span><\/p>\n

Goldberg L<\/span>, Haas ER, Urak R, Vyas V, Pathak KV, Garcia-Mansfield K, Pirrotte P, Singhal J, Figarola JL, Aldoss I, Forman SJ, Wang X. <\/span>\n Immunometabolic Adaptation of CD19-Targeted CAR T Cells in the Central Nervous System Microenvironment of Patients Promotes Memory Development<\/u>. Cancer Res. 2024 Apr 1;84(7):1048-1064. doi: 10.1158\/0008-5472.CAN-23-2299. PMID: 38315779; PMCID: PMC10984768.<\/span><\/p>\n

Goldberg L,<\/span> Haas ER, Vyas V, Urak R, Forman SJ, Wang X. <\/span>\n \n Single-cell analysis by mass cytometry reveals CD19 CAR T cell spatiotemporal plasticity in patients<\/u>\n <\/a>. Oncoimmunology. 2022 Feb 18;11(1):2040772. doi: 10.1080\/2162402X.2022.2040772. PMID: 35223193; PMCID: PMC8865283.<\/span><\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n

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Sarah Hill, MD, PhD<\/span><\/h1>\n <\/a>\n <\/div>\n <\/div>\n
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Defining an RB Functional Subtype  of Endometrial Cancer<\/span><\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n

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Endometrial Cancer<\/span><\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n

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Yang Z, Mogre S, Jun H, He R, Ghosh Chaudhary S, Bhattarai UR, Ho Sui SJ, Matulonis UA, Lazo S, Shetty A, Cameron A, Nguyen QD, <\/span>Hill SJ<\/strong>\n . <\/span>\n \n Functional Profiling of p53 and RB Cell Cycle Regulatory Proficiency Suggests Mechanism-Driven Molecular Stratification in Endometrial Carcinoma<\/u>\n <\/a>. Cancer Res Commun. 2025 Apr 1;5(4):719-742. doi: 10.1158\/2767-9764.CRC-24-0028. PMID: 39932274; PMCID: PMC12042793. <\/span><\/p>\n

Yang Z, Mogre S, He R, Berdan<\/span> EL, Ho Sui SJ, <\/span>Hill SJ<\/strong>\n . <\/span>\n \n The ORFIUS complex regulates ORC2 localization at replication origins<\/u>\n <\/a>. NAR Cancer. 2024 Jan 29;6(1):zcae003. doi: 10.1093\/narcan\/zcae003. PMID: 38288445; PMCID: PMC10823580. <\/span><\/p>\n

Wan C, Keany M, Dong H, Al-Alem LF, Pandya U, Lazo S, Boehnke K, Lynch KN, Xu R, Zarrella DT, Gu S, Cejas P, Lim K, Long H, Elias K, Horowitz N, Feltmate CM, Muto MG, Worley M, Berkowitz RS, Matulonis UA, Nucci MR, Crum CP, Rueda BR, Brown M, Liu XS, <\/span>\n Hill SJ<\/strong> <\/span>\n \n Enhanced efficacy of simultaneous PD-1 and PD-L1 immune checkpoint blockade in high grade serous ovarian cancer<\/u>\n <\/a>. Cancer Res. 2021 Jan 1;81(1):158-173. PMID: 33158814 PMCID: PMC7878408. <\/span><\/p>\n

Hill SJ<\/strong>, Rolland T, Adelmant G, Xia X, Owen MS, Dricot A, Zack TI, Sahni N, Jacob Y, Hao T, McKinney KM, Clark AP, Reyon D, Tsai SQ, Joung JK, Gaudet S, Beroukhim R, Marto JA, Vidal M, Hill DE, and Livingston DM. <\/span>\n \n Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage<\/u>\n <\/a>. Ge<\/span>nes Dev. 2014 Sep 1;28 (17):1957-75. PMID: 25184681; PMCID: PMC4197947.<\/span><\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n

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Arjun Kalra, MD<\/span><\/h1>\n <\/div>\n <\/div>\n
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Blood Cancer<\/span><\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n

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Carney KS, <\/span>Kalra AG,<\/strong> et al. (2026). <\/span>\n \n Immune Reconstitution Following Omidubicel Expanded Cord Blood Results In Accelerated NK Cell and CD4+ T-cell Recovery Compared with Alternative Graft Sources In Severe Aplastic Anemia (SAA)<\/u>\n <\/a>. Transplantation and Cellular Therapy, Official Publication of the American Society for Transplantation and Cellular Therapy 32(3): S12. <\/span><\/p>\n

Walter R, <\/span>Kalra A<\/strong>, Jarrett Z, Boster J, Rosas M, Stoffel S, Nugyen M, Morris M. (2023). <\/span>\n \n Single-Center Experience With the Seraph-100\u00ae Microbind\u00ae Affinity Blood Filter in Patients With SARS-CoV-2 Infection and Septic Shock at a Military Treatment Facility<\/u>\n <\/a>. Military Medicine, 188(7-8), e2670-e2674. https:\/\/doi.org\/10.1093\/milmed\/usad063<\/span><\/p>\n

Mintchev ME, <\/span>Kalra AG<\/strong>\n , Kou CJ, Aden JK, Bezzant ML, Dela Cruz WP, Bersabe AR. <\/span>\n \n Use of a Chemotherapy Toxicity Prediction Tool to Decrease Risks for Hospitalization in Older Patients<\/u>\n <\/a>\n .<\/u> Cureus. 2022 Apr 25;14(4):e24465. doi: 10.7759\/cureus.24465. PMID: 35497079; PMCID: PMC9045551.<\/span><\/p>\n

Dean JL, <\/span>Kalra AG<\/strong>, Gabasha S, Gore R. <\/span>\n \n Metastatic Cardiac Tumor Presenting as an Anteroseptal ST-Segment Elevation Myocardial Infarction in a Young Male<\/u>\n <\/a>. Cureus. 2021 Mar 18;13(3):e13981. doi: 10.7759\/cureus.13981. PMID: 33884235; PMCID: PMC8054945.<\/span><\/p>\n

K<\/span>apila V, <\/span>Kalra AG,<\/strong>\n Stockman DL. <\/span>\n \n A Non-Hereditary Case of Hereditary Leiomyomatosis and Renal Cell Carcinoma Syndrome<\/u>\n <\/a>. Cureus. 2021 Feb 15;13(2):e13344. doi: 10.7759\/cureus.13344. PMID: 33747650; PMCID: PMC7968348.<\/span><\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n

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Walter Kucera, MD<\/span><\/h1>\n <\/div>\n <\/div>\n
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Colorectal Cancer<\/span><\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n

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Kucera W<\/strong>, Olson TJP. <\/span>\n \n Loop ileostomy versus loop colostomy for fecal diversion<\/u>\n <\/a>. Seminars in Colon and Rectal Surgery. 2023 (34)2. doi:10.1016\/j.scrs.2023.100954.<\/span><\/p>\n

Devin CL, Gillani M, Shields MC, Eldridge K, <\/span>Kucera W, <\/strong>Rupji M, Purvis LA, Paul Olson TJ, Liu Y, Jarc A, Rosen SA. <\/span>\n \n Ratio of Economy of Motion: A New Objective Performance Indicator to Assign Console During Dual-Console Proctectomy<\/u>\n <\/a>. Am Surg (2023). 89: 3416-22.<\/span><\/p>\n

Josephs CA, Shaffer VO, <\/span>Kucera WB<\/strong>. <\/span>\n \n Impact of Mental Health on General Surgery Patients and Strategies to Improve Outcomes<\/u>\n <\/a>. Am Surg (2022). 89: 2636-2643.<\/span> doi: 10.1177\/00031348221109469 <\/span><\/p>\n

Nealeigh MD, <\/span>Kucera WB<\/strong>, Artino AR Jr, Bradley MJ, Meyer HS. <\/span>\n \n The Isolated Surgeon: A Scoping Review<\/u>\n <\/a>. J Surg Res (2021). 264: 562-571. doi: 10.1016\/j.jss.2020.12.032<\/span><\/p>\n

Franklin BR, Dyke C, Durning SJ, Artino AR, Bowyer MW, Nealeigh MD, <\/span>Kucera WB<\/span>\n , Ritter EM. <\/span>\n \n Piloting the FIRE: A Novel Error Management Training Simulation Curriculum for Fasciotomy Instruction<\/u>\n <\/a>. J Surg Educ. 2021 Mar-Apr;78(2):655-664. doi: 10.1016\/j.jsurg.2020.08.027. Epub 2020 Aug 29. PMID: 32873508.<\/span><\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n

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Shilpa Murthy, MD, MPH<\/h1>\n <\/div>\n <\/div>\n
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Project<\/h2>\n <\/div>\n <\/div>\n
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From Service to Survival:  Investigating the Associations Between Military Deployment and Early-Onset Colorectal Cancer Mortality in Veterans<\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n

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Colorectal Cancer<\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n

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Are C, Murthy SS, <\/strong>et al.\n \n Global Cancer Surgery: pragmatic solutions to improve cancer surgery outcomes worldwide<\/u>\n <\/a>.<\/span> Lancet Oncol. 2023 Dec;24(12): e472-e518 PMID: 37924819 DOI: 10.1016\/S1470-2045(23)00412-6<\/p>\n

Murthy SS, <\/strong>Are C.\n \n Cancer surgery on the global stage: Updates and progress<\/u>\n <\/a>. J Surg Oncol. 2024 Jan; 129(1):145-149 PMID: 38059658 DOI: 10.1002\/jso.27548<\/p>\n

Alatise OI, Allen H, Barton-Burke M, Abiodun AA, Ajayi AO, Ajayi N, Knapp GC, Kingham PT, Nigerian Endoscopy Collaborative, Murthy SS<\/strong>.\n \n Endoscopy capacity in Nigeria: a national needs assessment and recommendations<\/u>\n <\/a>.<\/span> Surg Endosc. 2025 Sept; 39 (9): 5698-5713 PMID: 40664926 DOI: 10.1007\/s00464-025-11874-3<\/p>\n

Allen H, Feng W, Falker CB, Brackett A, Brandt C, Agbafe V, Allen E, Bagga A, Esdaille J, Reddy V, Mongiu A, Macero N, Pantel H, Perkal M, Murthy SS<\/strong>.\n \n A Scoping Review of Surgical Care for People Experiencing Homelessness with Cancer<\/u>\n <\/a>. J Surg Oncol. 2026 Feb 11. PMID: DOI: 10.1002\/jso.70207<\/p>\n

Alatise O, Doyle A, Mohammed T, Arije O, Wuraola F, Olanrewaju O, Owoade I, Bojuwoye MO, Kahn R, Olcesse C, Esdaille J, Griffith S, Knapp G, Spence R, Ojumu T, Kingham TP, Murthy SS<\/strong>.\n \n A Pilot Randomized Cross-Over Trial Focused on Colonoscopy Skill Acquistion using High Fidelity Versus Low Fidelity Simulators in Nigeria<\/u>\n <\/a>. J Surg Educ. 2026 Jun; 83(6):103932 PMID: 41990515 DOI: 10.1016\/j.jsurg.2026.103932<\/p>\n

Murthy SS<\/strong>, Trapani D, Cao B, Bray F, Murthy S, Kingham TP, Are C, Ilbawi A.\n \n Premature mortality trends in 183 countries by cancer type, sex, WHO region, and World Bank income level in 2000-19: a retrospective, cross-sectional, population-based study<\/u>\n <\/a>. Lancet Oncol. 2024 July 1: S1470-2045(24)00274-2 PMID: 38964357 DOI: 10.1016\/S1470-2045(24)00274-2<\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n

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Hind Rafei, MD, MS<\/span><\/h1>\n <\/div>\n <\/div>\n
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Project<\/span><\/h2>\n <\/div>\n <\/div>\n
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Metabolic Rewiring  of CAR-T Cells to Counter the Hostile Tumor Microenvironment in Pancreatic Cancer<\/span><\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n

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Topic <\/span>Are<\/span>a<\/span><\/h2>\n <\/div>\n <\/div>\n
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Pancreatic Cancer<\/span><\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n

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Highlighted Publications<\/span><\/h3>\n <\/div>\n <\/div>\n
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Rafei H<\/strong>, Basar R, et al. <\/span>\n \n CREM is a regulatory checkpoint of CAR and IL-15 signaling in NK cells<\/u>\n <\/a>. <\/span>Nature<\/em>. 2025. doi: 10.1038\/s41586-025-09087-8. PubMed PMID: 40468083.

Marin D*, Li Y*, Basar R*, <\/span>\n Rafei H* (co-first author)<\/strong>, Daher M*, Dou J, Mohanty V, Dede M, Nieto Y, Uprety N, Acharya S, Liu E, Wilson J, Banerjee P, Macapinlac HA, Ganesh C, Thall PF, Bassett R, Ammari M, Rao S, Cao K, Shanley M, Kaplan M, Hosing C, Kebriaei P, Nastoupil LJ, Flowers CR, SM Moseley, Lin P, Ang S, Popat UR, Qazilbash MH, Champlin RE, Chen K, Shpall EJ, and Rezvani K. <\/span>\n \n Safety, efficacy and determinants of response of Allogeneic CD19-specific CAR-NK cells in CD19+ B cell tumors: a phase 1\/2 trial<\/u>\n <\/a>. <\/span>Nat Med<\/em>. 2024; PubMed PMID: 38400519.<\/span><\/p>\n

Li Y, Rezvani K, <\/span>Rafei H<\/strong>\n #<\/strong><\/sup>. <\/span>\n \n Next-generation chimeric antigen receptors for T- and natural killer-cell therapies against cancer<\/u>\n <\/a>. <\/span>Immunol Rev<\/em>. 2023 Aug 7; PubMed PMID: 37548050 (# corresponding author).<\/span><\/p>\n

Rafei H<\/strong>, Upadhyay R, Sharma P. A guide to CAR T cell therapies: development, current status and future prospects. <\/span>\n Nat Rev Immunol.<\/em> 2026 (In Press). <\/span><\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n

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John Rhee, MD, MPH<\/span><\/h1>\n <\/div>\n <\/div>\n
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LISTEN: Augmenting and Facilitating Communication in Brain Tumor Patients with Aphasia<\/span><\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n

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Topic Area<\/span><\/h2>\n <\/div>\n <\/div>\n
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Brain<\/span> <\/span>Cancer<\/span><\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n

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Highlighted Publications<\/span><\/h3>\n <\/div>\n <\/div>\n
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Rhee JY<\/strong>, Tentor Z, Sounack T, Durieux B, Miller PJ, Beroukhim R, Lindvall C. <\/span>\n \n Scalable tracking of symptoms in the electronic health record using large language models in patients with central nervous system cancers undergoing therapy<\/u>\n <\/a>. Neuro Oncol. 2026 Jan 1;28(1):206-217. doi: 10.1093\/neuonc\/noaf223. PMID: 40973180; PMCID: PMC12962643.<\/span><\/p>\n

Rhee JY<\/strong>, Miller P, Tentor Z, Reich A, Wright AA, Lindvall C. <\/span>\n \n A qualitative study with patients, care-partners, clinicians, and bioethicists to identify ethical considerations of artificial intelligence tools in palliative care<\/u>\n <\/a>. <\/span>Palliative Medicine<\/em>. 2026;40(5):667-677. doi:<\/span>\n 10.1177\/02692163251409290<\/span>\n <\/p>\n

Rhee JY<\/strong>, Miller P, Tentor Z, Vinh J, Tulsky J, Reich A, Wright A, Lindvall C. <\/span>\n \n When Is the Right Time? A Qualitative Study of Timing of Specialty Palliative Care in Patients with Brain Tumors<\/u>\n <\/a>.<\/span> <\/span>JCO Oncology Practice.<\/em> 2026. doi: 10.1200\/OP-25-01360<\/span><\/p>\n

Rhee JY<\/strong>, Mastrangelo C, Miller PJ, Youssef G, Tentor Z, Rothfeld-Wehrwein ZR, Dhongade VA, Nakhate V, Batchelor T, Dhand A. <\/span>\n \n A pilot study to quantify and describe personal social networks in patients with glioblastoma<\/u>\n <\/a>. Neurooncol Pract. 2025 Jan 8;12(3):426-436. doi: 10.1093\/nop\/npaf002. PMID: 40487576; PMCID: PMC12137218.<\/span><\/p>\n

Symons X, <\/span>Rhee JY<\/strong>, Tanous A, Balboni T, VanderWeele T. <\/span>\n \n Flourishing at the end of life<\/u>\n <\/a>. <\/span>Theoretical Medicine and Bioethics.<\/em> 2024. doi: 10.1007\/s11017-024-09679-x<\/span><\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n

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Daniel Sprague, MD, PhD<\/span><\/h1>\n <\/a>\n <\/div>\n <\/div>\n
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Investigating ARID1A Loss of Function to Develop Precision Targeted Therapeutics in Bladder Cancer<\/span><\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n

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Topic Area<\/span><\/h2>\n <\/div>\n <\/div>\n
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Bladder<\/span> <\/span>Cancer<\/span><\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n

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Highlighted Publications<\/span><\/h3>\n <\/div>\n <\/div>\n
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Yin S, Brobbey C, Ball L, Fu T,<\/strong> Sprague DJ<\/strong>\n , Gan W. <\/strong>\n \n BRD9 Functions as a Methylarginine Reader to Regulate AKT-EZH2 Signaling<\/u>\n <\/a>. <\/span>Sci. Adv. 11, eads6385 (2025). doi: 10.1126\/sciad.ads6385.<\/strong><\/p>\n

Sprague DJ<\/span>, <\/span>\n Park SK, Gramberg S, Bauer L, Rohr C, Chulkov E, Smith E, Scampavia L, Spicer T, Haeberlein S, Marchant J<\/span>.<\/em> <\/span>\n \n Target-based discovery of a broad-spectrum flukicide<\/u>\n <\/a>. <\/span>Nat Struct Mol Biol<\/em>\n  <\/span>31<\/strong>, 1386\u20131393 (2024). doi.org\/10.1038\/s41594-024-01298-3<\/span><\/p>\n

Sprague DJ, <\/strong>Getschman A, Fenske T, Volkman B, Smith B. <\/span>\n \n Trisubstituted 1,3,5-Triazines: The FIrst Ligands of the sY12-Binding Pocket on Chemokine CXCL12<\/u>\n <\/a>.<\/span> <\/span>ACS Med. Chem. Lett.<\/em> 2021, 12, 11, 1773-1782. doi: 10.1021\/acsmedchemlett.1c00388<\/span><\/p>\n

Dickinson CF, Potluri A, Bland AM, Flipse SM, Hanna GS, Wagner RT, Robertson KD, Ho TH, <\/span>Sprague DJ<\/strong>, Hoff GR, Stone RP, Tius MA, Tantillo DJ, Hamann MT. <\/span>\n \n On the Discorhabdins Leading to the Aleutianamine Ring System: A One-Step In Situ Transformation Characterized Through Computational and Experimental Studies and its Implications on Biosynthesis, Synthesis and Pharmacology<\/u>\n <\/a>. Angewandte Chemie International Edition. 65, no. 17 (2026): e7864883, https:\/\/doi.org\/10.1002\/anie.7864883<\/span><\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n

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Julea Vlassakis, PhD<\/span><\/h1>\n <\/a>\n <\/div>\n <\/div>\n
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Project<\/span><\/h2>\n <\/div>\n <\/div>\n
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Investigating ARID1A Loss of Function to Develop Precision Targeted Therapeutics in Bladder Cancer<\/span><\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n

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<\/span>Topic Area<\/span><\/h2>\n <\/div>\n <\/div>\n
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Sarcoma<\/span><\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n

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Highlighted Publications<\/span><\/h3>\n <\/div>\n <\/div>\n
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Vlassakis J<\/strong>, Hansen LL, Higuchi-Sanabria R, Zhou Y, Tsui CK, Dillin A, Huang H, Herr AE. <\/span>\n \n Measuring expression heterogeneity of single-cell cytoskeletal protein complexes<\/u>\n <\/a>. Nat Commun. 2021 Aug 17;12(1):4969. doi: 10.1038\/s41467-021-25212-3. PMID: 34404787; PMCID: PMC8371148.<\/span><\/p>\n

Baker J, Joseph N, Lao A, <\/span>Vlassakis J<\/span>\n . <\/span>\n \n Single-Cell Protein Assays in Context: From 2D to 3D and In Situ Analysis<\/u>\n <\/a>. <\/span>Annual Review Analytical Chemistry<\/em>\n . 19:95-120. doi: 10.1146\/annurev-anchem-101724-105925<\/span>\n <\/p>\n

Kang CC, Yamauchi K, <\/span>Vlassakis J<\/strong>\n , Sinkala E, Duncombe T, Herr A. <\/span>\n \n Single cell\u2013resolution western blotting<\/u>\n <\/a>. <\/span>Nat Protoc<\/em>\n  <\/span>11<\/strong>, 1508\u20131530 (2016). doi:10.1038\/nprot.2016.089<\/span><\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n

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Christine Zhang, PhD<\/span><\/h1>\n <\/div>\n <\/div>\n
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Uncovering Targetable Vulnerabilities in Leukemic Stem Cells<\/span><\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n

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<\/span>Topic Area<\/span><\/h2>\n <\/div>\n <\/div>\n
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Blood Cancer<\/span><\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n

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Highlighted Publications<\/span><\/h3>\n <\/div>\n <\/div>\n
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Xavier Raj I*, Kyun Koh W*, Harrison J*, <\/span>Zhang CR*<\/strong>, Soares B, Amato R, Krishnan A, O’Leary DR, Bjeije H, Parsons TM, Han W, Young AL, Wang T, Batista LFZ, Challen GA. <\/span>\n \n Non-canonical functions of DNMT3A in hematopoietic stem cells regulate telomerase activity and genome integrity<\/u>\n <\/a>. Cell Stem Cell. 2025 Jul 10; PubMed Central PMCID: PMC12313198. (*co-first author)<\/span><\/p>\n

Zhang CR,<\/strong> Ostrander EL, Kukhar O, Mallaney C, Sun J, Haussler E, Celik H, Koh WK, King KY, Gontarz P, Challen GA. <\/span>\n \n Txnip Enhances Fitness of Dnmt3a-Mutant Hematopoietic Stem Cells via p21<\/u>\n <\/a>. Blood Cancer Discov. 2022 May 5;3(3):220-239. PubMed Central PMCID: PMC9414740.<\/span><\/p>\n

Celik H, Krug E, <\/span>Zhang CR<\/strong>, Han W, Issa N, Koh WK, Bjeije H, Kukhar O, Allen M, Li T, Fisher DAC, Fowles JS, Wong TN, Stubbs MC, Koblish HK, Oh ST, Challen GA. <\/span>\n \n A Humanized Animal Model Predicts Clonal Evolution and Therapeutic Vulnerabilities in Myeloproliferative Neoplasms<\/u>\n <\/a>.<\/span> Cancer Discov. 2021 Dec 1;11(12):3126-3141. PubMed Central PMCID: PMC8716669.<\/span><\/p>\n

Zhang CRC<\/strong>, Nix D, Gregory M, Ciorba MA, Ostrander EL, Newberry RD, Spencer DH, Challen GA.<\/span>\n \n <\/u>\n <\/a>\n \n Inflammatory cytokines promote clonal hematopoiesis with specific mutations in ulcerative colitis patients<\/u>\n <\/a>.<\/span> Exp Hematol. 2019 Dec;80:36-41.e3. PubMed Central PMCID: PMC7031927.<\/span><\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"

COHORT4 Erik Blomain, MD, PhD Project Chemoradiation Imparts KRAS-Mediated Resistance to Immunotherapy in Non-Small Cell Lung Cancer Topic Area Lung Cancer Highlighted Publications Blomain ES, Soudi S, Wang Z, Somani A, Subramanian A, Nouth SCL, Oladipo E, New C, Kenney DE, Nemat-Gorgani N, Kindler T, Avedian RS, Steffner RJ, Mohler DG, Hiniker SM, Chin AL, […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"page-templates\/full-width-page.php","meta":{"content-type":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"class_list":["post-14839","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/csvcc.org\/index.php?rest_route=\/wp\/v2\/pages\/14839","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/csvcc.org\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/csvcc.org\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/csvcc.org\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/csvcc.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=14839"}],"version-history":[{"count":5,"href":"https:\/\/csvcc.org\/index.php?rest_route=\/wp\/v2\/pages\/14839\/revisions"}],"predecessor-version":[{"id":14870,"href":"https:\/\/csvcc.org\/index.php?rest_route=\/wp\/v2\/pages\/14839\/revisions\/14870"}],"wp:attachment":[{"href":"https:\/\/csvcc.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=14839"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}