{"id":13296,"date":"2025-07-03T17:59:26","date_gmt":"2025-07-04T00:59:26","guid":{"rendered":"https:\/\/csvcc.org\/?page_id=13296"},"modified":"2025-08-25T12:02:33","modified_gmt":"2025-08-25T19:02:33","slug":"colibri-13296","status":"publish","type":"page","link":"https:\/\/csvcc.org\/?page_id=13296","title":{"rendered":"— Scholars Research – Cohort 3"},"content":{"rendered":"
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COHORT 3<\/h1>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n
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Hussein Abbas, MD, PhD<\/span><\/h1>\n <\/div>\n <\/div>\n
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Project<\/span><\/h2>\n <\/div>\n <\/div>\n
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Organoid-Based Modeling and Therapeutic Targeting of TP53-Mutated Acute Myeloid Leukemia<\/span><\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n

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Topic Area<\/span><\/h2>\n <\/div>\n <\/div>\n
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Blood Cancer<\/span><\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n

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Highlighted Publications<\/span><\/h3>\n <\/div>\n <\/div>\n
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Reville PK, Wang B, Marvin-Peek J, Yuan B, Kuo YA, Garza AI, Dabbas B, Shariatmadar S, Thaper D, Ly CP, …, Andreeff M, <\/span>Abbas HA<\/strong>. <\/span>\n \n Blood-based proteomic profiling identifies OSMR as a novel biomarker of AML outcomes. Blood<\/u>\n <\/a>. 2025;145(25):3015-3029.<\/span><\/p>\n

Ly CP, Reville PK, Marvin-Peek J, Wang B, Yuan B, Kuo YA, Garza AI, Dabbas B, Shariatmadar S, Thaper D, Bhalla K… Andreeff M, <\/span>Abbas HA<\/strong>. <\/span>\n \n Multimodal spatial proteomic profiling in acute myeloid leukemia<\/u>\n <\/a>.<\/em> NPJ Precis Oncol. 2025;9(1):148.<\/span><\/p>\n

Wang Z, Skwarska A, Poigaialwar G, Chaudhry S, Rodriguez-Meira A, Sui P, Reville PK, Marvin-Peek J, Yuan B, Kuo YA…Ravandi F, Andreeff M, <\/span>Abbas HA<\/strong>\n . <\/span>\n \n Comprehensive characterization of IFN\u03b3 signaling in acute myeloid leukemia reveals prognostic and therapeutic strategies<\/u>\n <\/a>.<\/em> Nat Commun. 2024;15(1):1821.<\/span><\/p>\n

Guo S, Mohan GS, Wang B, Li T, Daver N, Zhao Y, Reville PK, Hao D, Patel KP, Loghavi S, Kantarjian H, DiNardo CD, Kadia TM, Konopleva M, Garcia-Manero G, Wang W, Wang SA, Short NJ, Kanagal-Shamanna R, Routbort MJ, Miranda RN, Medeiros LJ, Pemmaraju N, Ohanian M, Jabbour EJ, Cortes J, Bose P, Borthakur G, Andreeff M, <\/span>\n Abbas HA<\/strong>. <\/span>\n \n Paired single-B-cell transcriptomics and receptor sequencing reveal activation states and clonal signatures that characterize B cells in acute myeloid leukemia<\/u>\n <\/a>.<\/em> J Immunother Cancer. 2024;12(2):e008318.<\/span><\/p>\n

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Alissa Baker, MD<\/span><\/h1>\n <\/div>\n <\/div>\n
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Project<\/span><\/h2>\n <\/div>\n <\/div>\n
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Targeting Noncanonical Wnt Signaling to Prevent Ewing Sarcoma Metastases in a Novel Zebrafish Model<\/span><\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n

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Topic Area<\/span><\/h2>\n <\/div>\n <\/div>\n
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Sarcoma<\/span><\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n

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Highlighted Publications<\/span><\/h3>\n <\/div>\n <\/div>\n
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Hayashi M, <\/span>Baker A<\/strong>, Goldstein SD, Albert CM, Jackson KW, McCarty G, Kahlert UD, Loeb DM. <\/span>\n \n Inhibition of porcupine prolongs metastasis free survival in a mouse xenograft model of Ewing sarcoma<\/u>\n <\/a>. Oncotarget. 2017 Jul 21;8(45):78265-78276. doi: 10.18632\/oncotarget.19432. PMID: 29108227; PMCID: PMC5667961.<\/span><\/p>\n

Offenbacher R, Lazar P, Fabish L, Fox J, Lee A, Loeb DM, <\/span>Baker A<\/strong>. <\/span>\n \n Strategies for the Treatment of Desmoplastic Small Round Cell Tumor: A Case Series<\/u>\n <\/a>. Pediatr Blood Cancer. 2025 Jul;72(7):e31734. doi: 10.1002\/pbc.31734. Epub 2025 Apr 24. PMID: 40275528.<\/span><\/p>\n

Thomas RK, <\/span>Baker AC (co-first author)<\/strong>, et al. <\/span>\n \n High-throughput oncogene mutation profiling in human cancer<\/u>\n <\/a>. Nat Genet. 2007 Mar;39(3):347-51. doi: 10.1038\/ng1975. Epub 2007 Feb 11. Erratum in: Nat Genet. 2007 Apr;39(4):567. PMID: 17293865.<\/span><\/p>\n

Lin WM, <\/span>Baker AC (co-first author)<\/strong>, Beroukhim R, Winckler W, Feng W, Marmion JM, Laine E, Greulich H, Tseng H, Gates C, Hodi FS, Dranoff G, Sellers WR, Thomas RK, Meyerson M, Golub TR, Dummer R, Herlyn M, Getz G, Garraway LA. <\/span>\n \n Modeling genomic diversity and tumor dependency in malignant melanoma<\/u>\n <\/a>. Cancer Res. 2008 Feb 1;68(3):664-73. doi: 10.1158\/0008-5472.CAN-07-2615. PMID: 18245465; PMCID: PMC10493008.<\/span><\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n

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Edmond Chan, MD<\/span><\/h1>\n <\/div>\n <\/div>\n
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Project<\/span><\/h2>\n <\/div>\n <\/div>\n
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Advancing WRN as    a Promising Therapeutic Target for MSI-H Cancers <\/span><\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n

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Topic<\/span> <\/span>Area<\/span><\/h2>\n <\/div>\n <\/div>\n
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Colorectal Cancer<\/span><\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n

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Highlighted Publications<\/span><\/h3>\n <\/div>\n <\/div>\n
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Chan EM<\/strong>, Chhabra Y, Dixon KO, Durbin AD, F\u00e4rkkil\u00e4 A, Jeyasekharan AD, Keckesova Z, Prensner JR, Wagenblast E, Xie SZ, Zhao D.\n \n Insights on Future Directions in Cancer Research from the 2025 AACR NextGen Stars<\/u>\n <\/a>.<\/span> Cancer Discov. 2025 Apr 2;15(4):678-684.<\/p>\n

Borck PC, Boyle I, Jankovic K, Bick N, Foster K, Lau AC, Parker-Burns LI, Lubicki DA, Li T, Borah AA, Lofaso NJ, Das Sharma S, Chan T, Kishen RV, Adeagbo A, Raghavan S, Aquilanti E, Prensner JR, Krill-Burger JM, Golub TR, Campbell CD, Dempster JM, <\/span>Chan EM<\/strong>\n , Vazquez F. <\/span>\n \n SKI complex loss renders 9p21.3-deleted or MSI-H cancers dependent on PELO<\/u>\n <\/a>. Nature. 2025 Feb;638(8052):1104-1111. doi: 10.1038\/s41586-024-08509-3. Epub 2025 Feb 5.<\/span><\/p>\n

van Wietmarschen N, Sridharan S, Nathan WJ, Tubbs A, <\/span>Chan EM<\/strong>, Callen E, Wu W, Belinky F, Tripathi V, Wong N, Foster K, Noorbakhsh J, Garimella K, Cruz-Migoni A, Sommers JA, Huang Y, Borah AA, Smith JT, Kalfon J, Kesten N, Fugger K, Walker RL, Dolzhenko E, Eberle MA, Hayward BE, Usdin K, Freudenreich CH, Brosh RM Jr, West SC, McHugh PJ, Meltzer PS, Bass AJ, Nussenzweig A. <\/span>\n \n Repeat expansions confer WRN dependence in microsatellite-unstable cancers<\/u>\n <\/a>. Nature. 2020 Oct;586(7828):292-298. doi: 10.1038\/s41586-020-2769-8. Epub 2020 Sep 30.<\/span><\/p>\n

Chan EM<\/strong>, Shibue T, McFarland JM, Gaeta B, Ghandi M, et al. <\/span>\n \n WRN helicase is a synthetic lethal target in microsatellite unstable cancers<\/u>\n <\/a>. Nature. 2019 Apr;568(7753):551-556. doi: 10.1038\/s41586-019-1102-x. Epub 2019 Apr 10. PMID: 30971823; PMCID: PMC6580861.<\/span><\/p>\n

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Jonathan Chou, MD, PhD<\/span><\/h1>\n <\/div>\n <\/div>\n
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Strategies to Upregulate and Image NETCIN4 to Enhance NECTIN4 Targeted Therapies in Bladder Cancer<\/span><\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n

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Bladder Cancer<\/span><\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n

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Chang K, Delavan HM, Yip E, Kasap C, Zhu J, Lodha R, Liao SY, Berman SC, Carretero-Gonzalez A, Basar M, Ozcan G, Teo MY, Solit DB, Rosenberg JE, Al-Ahmadie H, Ding CCK, Chan E, Steri V, Porten SP, Koshkin VS, Friedlander TF, Feng FY, Lee JK, Wiita AP, Chu CE, <\/span>\n Chou J<\/strong>. Modulating the PPARg pathway upregulates NECTIN4 and enhances chimeric antigen receptor (CAR) T cell therapy in bladder cancer. In Press, Nat Commun.<\/span> <\/em><\/strong>\n 2025.<\/span>\n <\/p>\n

Yang H, Song H, Yip E, Gilpatrick T, Chang K, Allegakoen P, Lu KL, Hui K, Pham JH, Kasap C, Kumar V, Gayle J, Stohr BA, Cornelia Ding CK, Wiita AP, Meng MV, <\/span>Chou J<\/strong>\n , Porten SP, Huang FW. <\/span>\n \n Bladder cancer variants share aggressive features including a CA125+ cell state and targetable TM4SF1 expression<\/u>\n <\/a>. Nat Commun. 2025 Jun 17;16(1):5312. PMID: 40527915; PMCID: PMC12174346.<\/span><\/p>\n

Chu CE*, Sjostrom M, Egusa EA, Gibb EA, Badura ML, Zhu J, <\/span>Koshkin VS<\/strong>, Stohr BA, Meng MV, Pruthi RJ, Friedlander TW, Lotan Y, Black PC, Porten SP, Feng FY<\/span>\n #<\/sup> and <\/span>Chou J*<\/strong>\n #<\/strong><\/sup>. <\/strong>\n \n Heterogeneity in <\/u>NECTIN4 <\/u><\/em>\n expression across molecular subtypes of urothelial cancer mediates sensitivity to enfortumab vedotin<\/u>\n <\/a>. Clin Cancer Res<\/span>. <\/em>2021. (*equal contribution, <\/span>\n #<\/sup>co-corresponding author) (PMID: 34108177, PMCID: PMC8634828)<\/span><\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n

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Caner Saygin, MD<\/span><\/h1>\n <\/div>\n <\/div>\n
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Immunologic Drivers of Lineage Bias in TP53-Mutant Acute Leukemia<\/span><\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n

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Blood Cancer<\/span><\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n

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Saygin C<\/strong>, Giordano G, Shimamoto K, Eisfelder B, Thomas-Toth A, Venkataraman G, Ananthanarayanan V, Vincent TL, DuVall A, Patel AA, Chen Y, Tan F, Anthony SP, Chen Y, Shen Y, Odenike O, Teachey DT, Kee BL, LaBelle J, Stock W. <\/span>\n \n Dual targeting of apoptotic and signaling pathways in T-lineage acute lymphoblastic leukemia<\/u>\n <\/a>. <\/span>Clin Cancer Res. 2023 Aug 15;29(16):3151-3161. doi: 10.1158\/1078-0432.CCR-23-0415. PMID: 37363966; PMCID: PMC10425730.<\/span><\/p>\n

Saygin C<\/strong>, Zhang P, Stauber J, Aldoss I, Sperling AS, Weeks LD, Luskin MR, Knepper TC, Wanjari P, Wang P, Lager AM, Fitzpatrick C, Segal JP, Gharghabi M, Gurbuxani S, Venkataraman G, Cheng JX, Eisfelder BJ, Bohorquez O, Patel AA, Umesh Nagalakshmi S, Jayaram S, Odenike OM, Larson RA, Godley LA, Arber DA, Gibson CJ, Munshi NC, Marcucci G, Ebert BL, Greally JM, Steidl U, Lapalombella R, Shah BD, Stock W. <\/span>\n \n Acute lymphoblastic leukemia with myeloid mutations is a high-risk disease associated with clonal hematopoiesis<\/u>\n <\/a>. Blood Cancer Discov. 2024 May 1;5(3):164-179. doi: 10.1158\/2643-3230.BCD-23-0106. PMID: 38150184; PMCID: PMC11061587.<\/span><\/p>\n

Cooperrider JH, Karaoglu DA, Kubicki T, Jiang CR, Postich E, Shimamoto K, Arnold O, Macaraeg J, Ramsland A, Pula A, Kishtagari A, Pershad Y, Mack TM, Jones A, Bick AG, Savona M, Drazer MW, Dytfeld D, Jakubowiak A, Derman BA, <\/span>\n Saygin C<\/strong>. <\/span>\n \n Evolution of clonal hematopoiesis on and off lenalidomide maintenance for multiple myeloma<\/u>\n <\/a>. <\/span>Leukemia. 2025 Jul 16. doi: 10.1038\/s41375-025-02707-2. Epub ahead of print. PMID: 40670674.<\/span><\/p>\n

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Lindsay Schwartz, MD, MS<\/span><\/h1>\n <\/div>\n <\/div>\n
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Adaptation of an Inhaled Substance Use Intervention for Adolescent and Young Adult Cancer Survivors<\/span><\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n

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Topic Area<\/span><\/h2>\n <\/div>\n <\/div>\n
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Pediatric, Adolescent, and Young Adult Cancers<\/span><\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n

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Casillas J, <\/span>Schwartz L<\/strong>, Crespi C, Ganz P, Kahn K, Stuber M, Bastani R, Alquaddomi F, Estrin D. <\/span>\n \n The use of mobile technology and peer navigation to promote adolescent and young adult (AYA) cancer survivorship care: results of a randomized controlled trial<\/u>\n <\/a>. J Cancer Surviv. 2019 Aug;13(4):580-592. doi: 10.1007\/s11764-019-00777-7. Epub 2019 Jul 26. PMID: 31350681; PMCID: PMC7045289.<\/span><\/p>\n

Casillas J, <\/span>Schwartz L<\/strong>, Gildner J, Crespi C, Ganz P, Kahn K, Stuber M, Bastani R, Morales S, Quintana K, Gonzalez A, Casas E, Barboa E. <\/span>\n \n Engaging latino adolescent and young adult (AYA) cancer survivors in their care: piloting a photonovela intervention<\/u>\n <\/a>. <\/span>J Cancer Educ. 2021 Oct;36(5):971-980. doi: 10.1007\/s13187-020-01724-2. PMID: 32333369; PMCID: PMC10132777.<\/span><\/p>\n

Schwartz L<\/strong>, Tan M, McCrae J, Burkhardt T, Ness K, Henderson T. <\/span>\n \n Adverse childhood experiences and resilience in childhood and adolescent and young adult cancer patients<\/u>\n <\/a>. <\/span>Pediatr Blood Cancer. 2023 Mar;70(3):e30141. doi: 10.1002\/pbc.30141. Epub 2022 Dec 10. PMID: 36495237; PMCID: PMC10318856.<\/span><\/p>\n

Schwartz L<\/strong>, Shubeck S, Danielson E. <\/span>\n \n Young people with cancer: a growing population in need of united attention<\/u>\n <\/a>. <\/span>Curr Oncol Rep27<\/span>, 333\u2013335 (2025). https:\/\/doi.org\/10.1007\/s11912-025-01661-7<\/span><\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n

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Jonathan Tsai, MD, PhD<\/h1>\n <\/div>\n <\/div>\n
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Project<\/h2>\n <\/div>\n <\/div>\n
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Investigation of Menin\/KMT2A Protein Degradation for the Treatment of Myeloid Neoplasma<\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n

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Topic Area<\/h2>\n <\/div>\n <\/div>\n
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Blood Cancer<\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n

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Tsai JM<\/strong>, Nowak RP, Ebert BL, Fischer ES.\n \n Targeted protein degradation: from mechanisms to clinic<\/u>\n <\/a>. Nat Rev Mol Cell Biol. 2024 Sep;25(9):740-757. doi: 10.1038\/s41580-024-00729-9. Epub 2024 Apr 29. Review. PMID: 38684868. <\/p>\n

Tsai HK, Gogakos T, Lip V, Tsai JM<\/strong>, Li YD, Fisch AS, Weiss J, Yang W, Grimmett L, DiToro D, Schaefer EJ, Lindsley RC, Tran TH, Caron M, Langlois S, Sinnett D, Pikman Y, Nardi V, Kim AS, Silverman LB, Harris MH.\n \n Outlier expression of isoforms by targeted or total RNA sequencing identifies clinically significant genomic variants in hematolymphoid tumors<\/u>\n <\/a>. J Mol Diagn. 2023 Sep;25(9):665-681. doi: 10.1016\/j.jmoldx.2023.06.007. Epub 2023 Jul 5. PMID: 37419244; PMCID: PMC10488324.<\/p>\n

Tsai JM<\/strong>, Aguirre J, Li YD, Brown J, Focht V, Kater L…Ebert BL.\n \n UBR5 forms ligand-dependent complexes on chromatin to regulate nuclear hormone receptor stability<\/u>\n <\/a>. Mol Cell. 2023 Aug 3;83(15):2753-2767.e10. doi: 10.1016\/j.molcel.2023.06.028. Epub 2023 Jul 20. PMID: 37478846; PMCID: PMC11134608.<\/p>\n

Tsai JM<\/strong>, Hata A, Lennerz J.\n \n MET D1228N and D1246N are the same resistance mutation in MET exon 14 skipping<\/u>\n <\/a>. Oncologist. 2021 Dec;26(12):e2297-e2301. doi: 10.1002\/onco.13924. Epub 2021 Aug 17. PMID: 34347347; PMCID: PMC8649016.<\/p>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"

COHORT 3 Hussein Abbas, MD, PhD Project Organoid-Based Modeling and Therapeutic Targeting of TP53-Mutated Acute Myeloid Leukemia Topic Area Blood Cancer Highlighted Publications Reville PK, Wang B, Marvin-Peek J, Yuan B, Kuo YA, Garza AI, Dabbas B, Shariatmadar S, Thaper D, Ly CP, …, Andreeff M, Abbas HA. Blood-based proteomic profiling identifies OSMR as a […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"page-templates\/full-width-page.php","meta":{"content-type":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"class_list":["post-13296","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/csvcc.org\/index.php?rest_route=\/wp\/v2\/pages\/13296","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/csvcc.org\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/csvcc.org\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/csvcc.org\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/csvcc.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=13296"}],"version-history":[{"count":14,"href":"https:\/\/csvcc.org\/index.php?rest_route=\/wp\/v2\/pages\/13296\/revisions"}],"predecessor-version":[{"id":13641,"href":"https:\/\/csvcc.org\/index.php?rest_route=\/wp\/v2\/pages\/13296\/revisions\/13641"}],"wp:attachment":[{"href":"https:\/\/csvcc.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=13296"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}